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Eligibility criteria for the amitriptyline trial mark a major departure from two prior IC studies supported by NIDDK. In certain embodiments, either one or both of the gene encoding the revTetR repressor and the gene encoding the tetracycline-regulated indicator gene are integrated, for example, into the att site in Bacillus subtilis using bacteriophage Φ11 or, alternatively, integrated into the chromosome via homologous recombination into a specified gene (e.g., amiA gene; see Brucker 1997 FEMS Microbiol. Dr.Ogoni thank you very much for the good work in our lives and God will bless you for the good work you did.
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